Host Pathogen Variation & TB Pathogenesis (TBRU)

Dormancy regulon reduction was pivotal to the evolution of Mycobacterium tuberculosis

M Silcocks, JP Lingford, CY Cheung, WJ Jowsey, RM McCall, CD Rae, LK Harold, D Edwards, E Pepper-Tunick, SL Neville, MJ Maher, A Canalda-Baltrons, X Chang, PVK Thai, KE Holt, NS Baliga, GM Cook, TR Hawn, NTT Thuong, M Caws

2026-12-01

Phenotypically agnostic screens for positive selection in pathogen populations provide a means of pinpointing genes and regulatory..

Genome-wide association study reveals a novel tuberculosis susceptibility locus in multiple East Asian and European populations

X Chang, Z Li, PVK Thai, DTM Ha, NTT Thuong, D Wee, ASBM Subhan, M Silcocks, CBE Chee, NTQ Nhu, CK Heng, YY Teo, A Singhal, SH Oehlers, JM Yuan, WP Koh, M Caws, CC Khor, R Dorajoo, SJ Dunstan

2026-12-01

Background: Tuberculosis (TB) continues to be a leading cause of morbidity and mortality worldwide. Although numerous genome-wide ..

Host oxidative stress primes mycobacteria for rapid antibiotic resistance evolution

E Pepper-Tunick, V Srinivas, FD Mast, S Li, S Russ, W Hanson, AD Zamora, WJ Wu, M Silcocks, D Thi Minh Ha, SJ Dunstan, T Nguyen Thuy Thuong, S Turkarslan, JD Aitchison, ML Arrieta-Ortiz, NS Baliga

2026-12-01

The rapid emergence of multidrug-resistant Mycobacterium tuberculosis (Mtb) threatens global tuberculosis (TB) control, yet the me..

Host oxidative stress primes mycobacteria for rapid antibiotic resistance evolution.

Evan Pepper-Tunick, Vivek Srinivas, Fred D Mast, Song Li, Sagan Russ, Weston Hanson, Amy D Zamora, Wei-Ju Wu, Matthew Silcocks, Dang Thi Minh Ha, Sarah J Dunstan, Thuong Nguyen Thuy Thuong, Serdar Turkarslan, John D Aitchison, Mario L Arrieta-Ortiz, Nitin S Baliga

2025-12-04

The rapid emergence of multidrug-resistant Mycobacterium tuberculosis (Mtb) threatens global TB control, yet the mechanisms enabli..

Myeloid cell genome-wide screen identifies variants associated with Mycobacterium tuberculosis–induced cytokine transcriptional responses

JJ Ivie, KA Dill-McFarland, JD Simmons, GJ Peterson, PH Benchek, H Mayanja-Kizza, LE Veith, M Agata, DTM Ha, HDT Nghia, WH Boom, CM Stein, CC Khor, GE Thwaites, HT Hai, NTT Thuong, X Chang, SJ Dunstan, TR Hawn

2025-07-15

Immune and clinical outcomes to Mycobacterium tuberculosis (Mtb) infection vary greatly between individuals, yet the underlying ge..

Genome graphs reveal the importance of structural variation in Mycobacterium tuberculosis evolution and drug resistance

A Canalda-Baltrons, M Silcocks, MB Hall, D Theys, X Chang 常戌灵, LT Viberg, NL Sherry, L Coin, SJ Dunstan

2025-01-01

Structural variants (SVs) are increasingly recognized as key drivers of bacterial evolution, yet their role has not been explored ..

Evolution and transmission of antibiotic resistance is driven by Beijing lineage Mycobacterium tuberculosis in Vietnam

M Silcocks, X Chang, NT Thuong Thuong, Y Qin, DT Minh Ha, PV Khac Thai, S Vijay, DD Anh Thu, VT Ngoc Ha, HN Nhung, NH Lan, NT Quynh Nhu, D Edwards, A Nath, K Pham, ND Bang, TT Hong Chau, G Thwaites, AD Heemskerk, CC Khor

2023-12-01

A previous investigation has elucidated the landscape of Mtb genomic diversity and transmission dynamics in Ho Chi Minh City, Viet..

Parallel signatures of Mycobacterium tuberculosis and human Y-chromosome phylogeography support the Two Layer model of East Asian population history

M Silcocks, SJ Dunstan

2023-12-01

The Two Layer hypothesis is fast becoming the favoured narrative describing East Asian population history. Under this model, hunte..

MUC5AC Genetic Variation Is Associated With Tuberculous Meningitis Cerebral Spinal Fluid Cytokine Responses and Mortality

MC Sabo, NTT Thuong, X Chang, E Ardiansyah, TTB Tram, HT Hai, HDT Nghia, ND Bang, S Dian, AR Ganiem, S Shaporifar, V Kumar, Z Li, M Hibberd, CC Khor, GE Thwaites, D Heemskerk, A Van Laarhoven, R Van Crevel, SJ Dunstan

2023-08-01

Background: The purpose of this study was to assess if single nucleotide polymorphisms (SNPs) in lung mucins MUC5B and MUC5AC are ..